An AMPK activator
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EX-229

Item No. 34690

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yl]oxy]-2-methyl-benzoic acid
CAS Number
1219739-36-2
Synonyms
  • AMPK Activator 991
Molecular Formula
C24H18ClN3O3
Formula Weight
431.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.30 mg/ml
λmax
219, 235, 292 nm
SMILES
O=C(C1=CC(OC2=NC3=CC(Cl)=C(C4=CC(C=CN5C)=C5C=C4)C=C3N2)=CC=C1C)O
InChi Code
InChI=1S/C24H18ClN3O3/c1-13-3-5-16(10-17(13)23(29)30)31-24-26-20-11-18(19(25)12-21(20)27-24)14-4-6-22-15(9-14)7-8-28(22)2/h3-12H,1-2H3,(H,26,27)(H,29,30)
InChi Key
FHWSAZXFPUMKFL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $202

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    10 mg

    $329

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    25 mg

    $587

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    EX-229 is an activator of AMP-activated protein kinase (AMPK).1 It activates AMPK and increases glucose uptake in isolated rat epitrochlearis muscle when used at a concentration of 100 µM. EX-229 also increases AMPK activation and glucose uptake in primary skeletal muscle cultures isolated from patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lai, Y.-C., Kviklyte, S., Vertommen, D., et al. A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: Comparison with effects of contraction and other AMPK activators. Biochem. J. 460(3), 363-375 (2014).

    2. Brown, A.E., Dibnah, B., Fisher, E., et al. Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS. Biosci. Rep. 38(3), BSR20180242 (2018).