An internal standard for the quantification of fisetin
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Unlabeled Version(s)
15246Fisetin
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Fisetin-d5

Item No. 34706

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dihydroxyphenyl-2,5,6-d3)-3,7-dihydroxy-4H-1-benzopyran-4-one-6,8-d2
CAS Number
2909407-29-8
Molecular Formula
C15H5D5O6
Formula Weight
291.3
Purity
≥99% deuterated forms (d1-d5)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 5 mg/ml
SMILES
O=C1C2=C(C([2H])=C(O)C([2H])=C2)OC(C3=C([2H])C(O)=C(O)C([2H])=C3[2H])=C1O
InChi Code
InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H/i1D,2D,4D,5D,6D
InChi Key
XHEFDIBZLJXQHF-UPLZBMDUSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    Product Description

    Fisetin-d5 is intended for use as an internal standard for the quantification of fisetin (Item No. 15246) by GC- or LC-MS. Fisetin is a flavonoid that has been found in various fruits and vegetables and has diverse biological activities.1,2,3,4 It scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay and inhibits oxidative burst induced by N-Formyl-Met-Leu-Phe (fMLP; Item No. 21495) in isolated human polymorphonuclear neutrophils (PMNs) when used at a concentration of 10 µM.1,3 Fisetin (10-60 µM) induces cell cycle arrest at the G1 phase and apoptosis in, as well as inhibits the proliferation of, LNCaP prostate cancer cells.2 It inhibits LPS-induced production of nitrite, prostaglandin E2 (PGE2; Item No. 14010), and NF-κB activation in RAW 264.7 cells.3 Fisetin (1 mg/animal) reduces tumor growth in a CWR22Rυ1 prostate cancer mouse xenograft model.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Khan, N., Syed, D.N., Ahmad, N., et al. Fisetin: A dietary antioxidant for health promotion. Antioxid. Redox Signal. 19(2), 151-162 (2013).

    2. Khan, N., Afaq, F., Syed, D.N., et al. Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells. Carcinogenesis 29(5), 1049-1056 (2008).

    3. Wang, L., Tu, Y.-C., Lian, T.-W., et al. Distinctive antioxidant and antiinflammatory effects of flavonols. J. Agric. Food Chem. 54(26), 9798-9804 (2006).

    4. Khan, N., Asim, M., Afaq, F., et al. A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice. Cancer Res. 68(20), 8555-8563 (2008).