An orexin receptor 2 antagonist
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MK-3697

Item No. 34718

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(5,6-dimethoxy-2-pyridinyl)methyl]-5′-methyl-5-(2-thiazolyl)-[2,3′-bipyridine]-4-carboxamide
CAS Number
1224846-01-8
Molecular Formula
C23H21N5O3S
Formula Weight
447.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:2): 0.33 mg/mlDMSO: 1 mg/ml
λmax
290, 316 nm
SMILES
O=C(C1=CC(C2=CN=CC(C)=C2)=NC=C1C3=NC=CS3)NCC4=CC=C(OC)C(OC)=N4
InChi Code
InChI=1S/C23H21N5O3S/c1-14-8-15(11-24-10-14)19-9-17(18(13-26-19)23-25-6-7-32-23)21(29)27-12-16-4-5-20(30-2)22(28-16)31-3/h4-11,13H,12H2,1-3H3,(H,27,29)
InChi Key
VSOUDUXMPUHJEU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $81

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    10 mg

    $158

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    25 mg

    $306

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    50 mg

    $479

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    Product Description

    MK-3697 is an orexin receptor 2 (OX2R) antagonist (Ki = 1.1 nM).1 It is selective for OX2R over OX1R (Ki = 3,600 nM). MK-3697 decreases active awake time and increases slow wave sleep (SWS) and rapid eye movement (REM) sleep in mice when administered at a dose of 100 mg/kg. It also decreases active awake time and increases phase II SWS in dogs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roecker, A.J., Reger, T.S., Mattern, M.C., et al. Discovery of MK-3697: A selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia. Bioorg. Med. Chem. Lett. 24(20), 4884-4890 (2014).