A genotoxic derivative of (±)-atenolol
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Product Type

Biochemicals

N-Nitroso Atenolol

Item No. 34735

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-hydroxy-3-[(1-methylethyl)nitrosoamino]propoxy]-benzeneacetamide
CAS Number
134720-04-0
Synonyms
  • NO-Atenolol
Molecular Formula
C14H21N3O4
Formula Weight
295.3
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble
λmax
229 nm
SMILES
O=NN(C(C)C)CC(COC1=CC=C(CC(N)=O)C=C1)O
InChi Code
InChI=1S/C14H21N3O4/c1-10(2)17(16-20)8-12(18)9-21-13-5-3-11(4-6-13)7-14(15)19/h3-6,10,12,18H,7-9H2,1-2H3,(H2,15,19)
InChi Key
BLORPAGHSJJNFB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $190

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    10 mg

    $354

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    Product Description

    N-Nitroso atenolol is a genotoxic derivative of (±)-atenolol (Item No. 17250).1 It induces DNA fragmentation in rat hepatocytes when used at concentrations ranging from 0.1 to 1 mM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Robbiano, L., Martelli, A., Allavena, A., et al. Formation of the N-nitroso derivatives of six β-adrenergic-blocking agents and their genotoxic effects in rat and human hepatocytes. Cancer Res. 51(9), 2273-2279 (1991).