An internal standard for the quantification of L-valine
Related Products
Unlabeled Version(s)
38709L-Valine
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L-Valine-d8

Item No. 34830

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-valine-2,3,4,4,4,4′,4′,4′-d8
CAS Number
35045-72-8
Synonyms
  • (+)-Valine
  • (S)-Valine
Molecular Formula
C5H3D8NO2
Formula Weight
125.2
Purity
≥99% deuterated forms (d1-d8)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
SMILES
[2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])[C@@](N)([2H])C(O)=O
InChi Code
InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1/i1D3,2D3,3D,4D
InChi Key
KZSNJWFQEVHDMF-AYWPRJOCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $185

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    10 mg

    $341

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    25 mg

    $653

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    Product Description

    L-Valine-d8 is intended for use as an internal standard for the quantification of L-valine (Item No. 38709) by GC- or LC-MS. L-Valine is a branched-chain essential amino acid that is obtained via the diet.1 It is considered glucogenic due to its catabolism that ultimately forms succinyl-CoA, which enters the citric acid cycle.2 A deficiency in branched-chain dehydrogenase, the enzyme that catabolizes valine, isoleucine, and leucine, leads to maple syrup urine disease, a disorder characterized by progressive ketoacidosis, failure to thrive, neurological dysfunction, and, potentially, death.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berg, J.M., Tymoczko, J.L., and Stryer, L. Biochemistry. (2002).

    2. Massey, K.A., Blakeslee, C.H., and Pitkow, H.S. A review of physiological and metabolic effects of essential amino acids. Amino Acids 14(4), 271-300 (1998).

    3. Farias, H.R., Gabriel, J.R., Cecconi, M.L., et al. The metabolic effect of α-ketoisocaproic acid: In vivo and in vitro studies. Metab. Brain Dis. 36(1), 185-192 (2021).