An internal standard for the quantification of L-arginine
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Alternative(s)
9004088L-Arginine-13C6 (hydrochloride)
Unlabeled Version(s)
23703L-Arginine (hydrochloride)
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L-Arginine-d7 (hydrochloride)

Item No. 34834

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginine-2,3,3,4,4,5,5-d7, monohydrochloride
CAS Number
204244-77-9
Synonyms
  • L-(+)-Arginine-d7
Molecular Formula
C6H7D7N4O2 • HCl
Formula Weight
217.7
Purity
≥99% deuterated forms (d1-d7)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
N=C(N)NC([2H])([2H])C([2H])([2H])C([2H])([2H])[C@@](N)([2H])C(O)=O.Cl
InChi Code
InChI=1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1/i1D2,2D2,3D2,4D;
InChi Key
KWTQSFXGGICVPE-AHQNDZJWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    L-Arginine-d7 is intended for use as an internal standard for the quantification of L-arginine (Item No. 23703) by GC- or LC-MS. L-Arginine is an amino acid and a precursor of nitric oxide (NO).1 L-Arginine is a substrate for NO synthase that is oxidized to form NO and L-citrulline. It enhances NO release induced by bradykinin (Item No. 37408) or A23187 (Item No. 11016) in porcine aortic endothelial cells.2 L-Arginine (30 and 300 mg/kg, i.v.) induces dilation of pial arterioles and increases cerebral blood flow in normotensive and spontaneously hypertensive rats.3 It also reduces infarct size by 35 and 28% in normotensive and spontaneously hypertensive rats, respectively, following middle cerebral artery occlusion.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stuehr, D.J. Enzymes of the L-arginine to nitric oxide pathway. J. Nutr. 134(10 Suppl), 2748S-2751S (2004).

    2. Palmer, R.M.J., Ashton, D.S., and Moncada, S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 333(6174), 664-666 (1988).

    3. Morikawa, E., Moskowitz, M.A., Huang, Z., et al. L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke 25(2), 429-435 (1994).