An internal standard for the quantification of L-lysine
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Unlabeled Version(s)
36455L-Lysine (hydrochloride)
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L-Lysine-d3 (hydrochloride)

Item No. 34844

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysine-2,6,6-d3, monohydrochloride
CAS Number
2330878-43-6
Molecular Formula
C6H11D3N2O2 • HCl
Formula Weight
185.7
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
N[C@](CCCC([2H])([2H])N)([2H])C(O)=O.Cl
InChi Code
InChI=1S/C6H14N2O2.ClH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m0./s1/i4D2,5D;
InChi Key
BVHLGVCQOALMSV-FUVXPQFCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    L-Lysine-d3 is intended for use as an internal standard for the quantification of L-lysine by GC- or LC-MS. L-Lysine is an essential amino acid.1 It is catabolized via the saccharopine pathway to produce acetyl-coenzyme A (acetyl-CoA; Item No. 16160) in liver mitochondria. L-Lysine is also a precursor in the biosynthesis of L-carnitine (Item No. 21489), a conditionally essential nutrient that has roles in energy production and fatty acid metabolism.2 L-Lysine (400 mg/kg per day) reduces viral shedding in cats latently infected with feline herpesvirus type 1 (FHV-1).3 Administration of an L-lysine-deficient diet increases fecal pellet excretion induced by restraint stress, indicating increases in anxiety, in rats.4 Formulations containing L-lysine have been used as dietary supplements.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Leandro, J., and Houten, S.M. Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin. J. Cell Biol. 218(2), 391-392 (2019).

    2. Flanagan, J.L., Simmons, P.A., Vehige, J., et al. Role of carnitine in disease. Nutr. Metab. 7(30), (2010).

    3. Maggs, D.J., Nasisse, M.P., and Kass, P.H. Efficacy of oral supplementation with L-lysine in cats latently infected with feline herpesvirus. Am. J. Vet. Res. 64(1), 37-42 (2003).

    4. Smriga, M., Kameishi, M., Uneyama, H., et al. Dietary L-lysine deficiency increases stress-induced anxiety and fecal excretion in rats. J. Nutr. 132(12), 3744-3746 (2002).