An internal standard for the quantification of berberine
Related Products
Unlabeled Version(s)
10006427Berberine (chloride)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Berberine-d6 (chloride)

Item No. 34851

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6-dihydro-9,10-dimethoxy-d6-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, monochloride
Synonyms
  • BBR-d6
  • Umbellatine-d6
Molecular Formula
C20H12D6NO4 • Cl
Formula Weight
377.9
Purity
≥99% deuterated forms (d1-d6)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
[2H]C([2H])([2H])OC1=CC=C2C(C=[N+]3CCC4=C(C3=C2)C=C5OCOC5=C4)=C1OC([2H])([2H])[2H].[Cl-]
InChi Code
InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1/i1D3,2D3;
InChi Key
VKJGBAJNNALVAV-TXHXQZCNSA-M
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $370

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Berberine-d6 is intended for use as an internal standard for the quantification of berberine (Item No. 10006427) by GC- or LC-MS. Berberine is an isoquinoline alkaloid that has been found in C. fenestratum and has diverse biological activities.1,2,3,4,5 It induces frameshift mutations and gene crossovers in haploid and diploid strains of S. cerevisiae, respectively, in the exponential growth phase when used at a concentration of 50 µg/ml.2 Berberine is active against the S. aureus strains ATCC 25922 and NCTC 8530 (MIC = 250 µg/ml for both).3 It decreases contusion volume, ventricle enlargement, and neurological deficits in a mouse model of controlled cortical impact-induced traumatic brain injury (TBI) when administered at a dose of 10 mg/kg.4 Berberine (50 mg/kg) reduces serum LDL cholesterol levels in hamsters fed a high-fat high-cholesterol diet.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Malhotra, S., Taneja, S.C., and Dhar, K.L. Minor alkaloid from Coscinium fenestratum. Phytochem. 28(7), 1998-1999 (1989).

    2. Pasqual, M.S., Lauer, C.P., Moyna, P., et al. Genotoxicity of the isoquinoline alkaloid berberine in prokaryotic and eukaryotic organisms. Mutat. Res. 286(2), 243-252 (1993).

    3. Iwasa, K., Kamigauchi, M., Ueki, M., et al. Antibacterial activity and structure-activity relationships of berberine analogs. Eur. J. Med. Chem. 31(6), 469-478 (1996).

    4. Chen, C.C., Hung, T.H., Lee, C.Y., et al. Berberine protects against neuronal damage via suppression of glia-mediated inflammation in traumatic brain injury. PLoS One 9(12), e115694 (2014).

    5. Kong, W., Wei, J., Abidi, P., et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat. Med. 10(12), 1344-1351 (2004).