An HDAC3 inhibitor
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BRD3308

Item No. 34875

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(acetylamino)-N-(2-amino-4-fluorophenyl)-benzamide
CAS Number
1550053-02-5
Molecular Formula
C15H14FN3O2
Formula Weight
287.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
243, 286, 303 nm
SMILES
O=C(C1=CC=C(NC(C)=O)C=C1)NC2=CC=C(C=C2N)F
InChi Code
InChI=1S/C15H14FN3O2/c1-9(20)18-12-5-2-10(3-6-12)15(21)19-14-7-4-11(16)8-13(14)17/h2-8H,17H2,1H3,(H,18,20)(H,19,21)
InChi Key
RRJDFENBXIEAPD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $81

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    10 mg

    $145

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    25 mg

    $317

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    50 mg

    $475

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    BRD3308 is an inhibitor of histone deacetylase 3 (HDAC3; Ki = 29 nM).1 It is selective for HDAC3 over HDAC1 and HDAC2 (Kis = 6,300 and 5,100 nM, respectively). BRD3308 (10 µM) reduces cytokine-induced increases in apoptosis in rat INS-1E β cells. In vivo, BRD3308 (5 mg/kg) reduces plasma glucose levels in rats and increases plasma insulin levels in rats in a hyperglycemic clamp assay as a model of type 2 diabetes.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1.  An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chem. Biol. 11(2), 363-374 (2016).

    2. Lundh, M., Galbo, T., Poulsen, S.S., et al. Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats. Diabetes Obes. Metab. 17(7), 703-707 (2015).