Host: HEK293 cells • AA: 20-301 (CD1d), 21-119 (β2-microglobulin) • Tag: C-terminal His (CD1d) • MW: 33 (CD1d) and 12 (β2-microglobulin) kDa
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CD1d Extracellular Domain/β2-Microglobulin Complex (human, recombinant)

Item No. 34877

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Antigen-presenting Glycoprotein CD1d
  • B2M
  • β2-Microprotein
  • R3G1
Purity
≥90%
Source
Recombinant human C-terminal His-tagged CD1d extracellular domain and β2-microglobulin expressed in HEK293 cells
Amino Acids
20-301 (CD1d), 21-119 (β2-microglobulin)
MW
33 (CD1d) and 12 (β2-microglobulin) kDa
Formulation (Request formulation change)
50 mM Tris HCl, pH 8.0, 150 mM sodium chloride
Host
HEK293 cells
SMILES
O=C(NC1=C(N(CC(C)C)CC(C)C)C=CC(C2=C(C3=NN=NN3)C=CC=C2)=C1)NC4=CC=C(C)C=C4
InChi Code
InChI=1S/C29H35N7O/c1-19(2)17-36(18-20(3)4)27-15-12-22(24-8-6-7-9-25(24)28-32-34-35-33-28)16-26(27)31-29(37)30-23-13-10-21(5)11-14-23/h6-16,19-20H,17-18H2,1-5H3,(H2,30,31,37)(H,32,33,34,35)
InChi Key
CJNMMPAEIYFQIJ-UHFFFAOYSA-N
UniProt Accession №
P15813 (CD1d), P61769 (B2M)
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $396

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    Product Description

    CD1d is a lipid antigen-presenting molecule and a member of the group II CD1 family expressed by humans and mice.1 It is composed of a heavy chain, a transmembrane region, and a short intracellular C-terminal tail.1 The heavy chain contains three extracellular domains that associate with the light-chain β2-microglobulin. It is expressed primarily by antigen-presenting cells.1,2 CD1d is directly involved in the process of presenting lipid antigens to T cells and invariant natural killer T (iNKT) cells to induce an immune response, including the secretion of specific cytokines depending on the antigen presented. Activation of iNKT cells by CD1d presentation of α-galactosylceramide (α-GalCer) in a murine model of melanoma reduces the number of metastases, but only when bone marrow-derived dendritic cells (BMDCs) were used to prolong iNKT cell responses.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Florence, W.C., Bhat, R.K., and Joyce, S. CD1d-restricted glycolipid antigens: Presentation principles, recognition logic and functional consequences. Expert. Rev. Mol. Med. 10, e20 (2008).

    2. Joyce, S. CD1d and natural T cells: How their properties jump-start the immune system. Cell Mol. Life Sci. 58(3), 442-469 (2001).

    3. Wen, X., Rao, P., Carreño, L.J., et al. Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells. Proc. Natl. Acad. Sci. USA 110(8), 2963-2968 (2013).