A STING antagonist
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SN-011

Item No. 34890

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-[1,1′-biphenyl]-4-carboxamide
CAS Number
2249435-90-1
Synonyms
  • GUN35901
Molecular Formula
C25H19FN2O4S
Formula Weight
462.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 25 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): insol
λmax
277 nm
SMILES
O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC3=CC=C(C(NS(=O)(C4=CC=C(C=C4)F)=O)=C3)O
InChi Code
InChI=1S/C25H19FN2O4S/c26-20-10-13-22(14-11-20)33(31,32)28-23-16-21(12-15-24(23)29)27-25(30)19-8-6-18(7-9-19)17-4-2-1-3-5-17/h1-16,28-29H,(H,27,30)
InChi Key
GPXQUPCJIJBXHJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    SN-011 is a stimulator of interferon genes (STING) antagonist.1 It binds to the STING cyclic dinucleotide binding site (Kd = 4.03 nM) and inhibits 2'3'-cGAMP-induced Ifnb expression in mouse embryonic fibroblasts (MEFs), mouse bone marrow-derived macrophages (BMDMs), and human foreskin fibroblasts (HFFs; IC50s = 127.5, 107.1, and 502.8 nM, respectively). SN-011 (1 µM) impairs recruitment of IFN regulatory factor 3 (IRF3) or TANK-binding kinase 1 (TBK1) to the STING signalosome in HEK293T cells overexpressing tagged wild-type or SAVI-linked mutant STING and IRF3 or TBK1, as well as inhibits translocation of STING from the endoplasmic reticulum (ER) to the Golgi induced by herpes simplex virus 1 (HSV-1) in HFFs. In vivo, SN-011 (5 mg/kg) increases survival and reduces Ifnb mRNA levels in the Trex1-/- mouse model of Aicardi-Goutières syndrome, an autoimmune disorder characterized by constitutive activation of cGAS and IFN overproduction.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hong, Z., Mei, J., Li, C., et al. STING inhibitors target the cyclic dinucleotide binding pocket. Proc. Natl. Acad. Sci. USA 118(24), e2105465118 (2021).