An agonist of GPR119
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AR231453

Item No. 34898

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-fluoro-4-(methylsulfonyl)phenyl]-6-[4-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-5-nitro-4-pyrimidinamine
CAS Number
733750-99-7
Molecular Formula
C21H24FN7O5S
Formula Weight
505.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 3 mg/ml
λmax
285, 358 nm
SMILES
FC1=CC(S(=O)(C)=O)=CC=C1NC2=C([N+]([O-])=O)C(N3CCC(CC3)C4=NC(C(C)C)=NO4)=NC=N2
InChi Code
InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25)
InChi Key
DGBKNTVAKIFYNU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $183

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    25 mg

    $402

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    50 mg

    $702

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    AR231453 is an agonist of GPR119.1 It increases cAMP accumulation in HIT-T15 β cells that endogenously express high levels of GPR119 (EC50 = 4.7 nM). AR231453 increases insulin release from HIT-T15 cells (EC50 = 3.5 nM) and increases glucose-induced insulin release in isolated rat and mouse islets. It reduces plasma glucose levels in wild-type, KK/Ay, and db/db diabetic mice when administered at a dose of 20 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chu, Z.L., Jones, R.M., He, H., et al. A role for ß-cell-expressed GPR119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology 148(6), 2601-2609 (2007).