A β-AR antagonist
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Bupranolol

Item No. 34902

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2-chloro-5-methylphenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol
CAS Number
14556-46-8
Synonyms
  • (±)-Bupranolol
Molecular Formula
C14H22ClNO2
Formula Weight
271.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2) (1:4): 0.20 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
SMILES
ClC1=CC=C(C)C=C1OCC(CNC(C)(C)C)O
InChi Code
InChI=1S/C14H22ClNO2/c1-10-5-6-12(15)13(7-10)18-9-11(17)8-16-14(2,3)4/h5-7,11,16-17H,8-9H2,1-4H3
InChi Key
HQIRNZOQPUAHHV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $36

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    100 mg

    $68

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    Product Description

    Bupranolol is an antagonist of β-adrenergic receptors (β-ARs; Kis = 6-15 nM for β1- and β2-ARs).1 In vivo, bupranolol (10 µmol/kg) reduces heart rate and diastolic blood pressure in pithed rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wellstein, A., Küppers, H., Pitschner, H.F., et al. Transdermal delivery of bupranolol: Pharmacodynamics and beta-adrenoceptor occupancy. Eur. J. Clin. Pharmacol. 31(4), 419-422 (1986).

    2. Malinowska, B., Kieć-Kononowicz, K., Flau, K., et al. Atypical cardiostimulant β-adrenoceptor in the rat heart: Stereoselective antagonism by bupranolol but lack of effect by some bupranolol analogues. Br. J. Pharmacol. 139(8), 1548-1554 (2003).