An active metabolite of trimipramine
Related Products
Isomer(s)
15890Imipramine (hydrochloride)
Parent Compound(s)
15921Trimipramine (maleate)
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N-desmethyl Trimipramine

Item No. 34982

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10,11-dihydro-N,β-dimethyl-5H-dibenz[b,f]azepine-5-propanamine
CAS Number
2293-21-2
Synonyms
  • Monodesmethyltrimipramine
  • Nortrimipramine
Molecular Formula
C19H24N2
Formula Weight
280.4
Purity
≥95%
Formulation (Request formulation change)
A 5 mg/ml solution in methanol
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly solubleMethanol: Slightly soluble
λmax
250 nm
SMILES
CC(CNC)CN(C1=C(CC2)C=CC=C1)C3=C2C=CC=C3
InChi Code
InChI=1S/C19H24N2/c1-15(13-20-2)14-21-18-9-5-3-7-16(18)11-12-17-8-4-6-10-19(17)21/h3-10,15,20H,11-14H2,1-2H3
InChi Key
FUEUKSCRQNPXKS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $82

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    1 mg

    $154

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    5 mg

    $643

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    Product Description

    N-desmethyl Trimipramine is an active metabolite of the tricyclic antidepressant trimipramine (Item No. 15921).1 It inhibits the norepinephrine transporter (NET), serotonin (5-HT) transporter (SERT), and dopamine transporter (DAT; IC50s = 2.92, 6.22, and 29.5 µM, respectively) as well as organic cation transporter 1 (OCT1) and OCT2 (IC50s = 3.19 and 10.4 µM, respectively) in HEK293 cells expressing the human transporters.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Haenisch, B., Hiemke, C., and Bönisch, H. Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters. Psychopharmacology (Berl) 217(2), 289-295 (2011).