An internal standard for the quantification of alfuzosin
Related Products
Unlabeled Version(s)
13648Alfuzosin (hydrochloride)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Alfuzosin-d7

Item No. 34999

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furan-2,3,3,4,4,5,5-d7-carboxamide
CAS Number
1133386-93-2
Synonyms
  • SL 77499-10-d7
  • Uroxatral-d7
Molecular Formula
C19H20D7N5O4
Formula Weight
396.5
Purity
≥99% deuterated forms (d1-d7)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
250 nm
SMILES
NC1=NC(N(C)CCCNC(C2([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])O2)=O)=NC3=C1C=C(OC)C(OC)=C3
InChi Code
InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23)/i4D2,6D2,9D2,14D
InChi Key
WNMJYKCGWZFFKR-BCIKGFBOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $70

    Add

    1 mg

    $124

    Add

    5 mg

    $512

    Add

    10 mg

    $884

    Add
    Product Description

    Alfuzosin-d7 is intended for use as an internal standard for the quantification of alfuzosin (Item No. 13648) by GC- or LC-MS. Alfuzosin is an antagonist of α1-adrenergic receptors (α1-ARs; Kis = 10, 10, and 3.16 nM for α1A-, α1B-, and α1D-ARs, respectively).1 It increases the amount of phenylephrine needed to increase urethral and arterial blood pressure in pithed rats when administered at a dose of 10 mg/kg.2 Formulations containing alfuzosin have been used in the treatment of benign prostatic hyperplasia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kenny, B.A., Miller, A.M., Williamson, I.J.R., et al. Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: Binding, functional and in vivo studies. Br. J. Pharmacol. 118(4), 871-878 (1996).

    2. Martin, D.J., Lluel, P., Pouyet, T., et al. Relationship between the effects of alfuzosin on rat urethral and blood pressures and its tissue concentrations. Life Sci. 63(3), 169-176 (1998).