A 5-HT2A receptor antagonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

4F 4PP (oxalate)

Item No. 35005

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4-fluorophenyl)[1-(4-phenylbutyl)-4-piperidinyl]-methanone, monoethanedioate
CAS Number
144734-36-1
Molecular Formula
C22H26FNO • C2H2O4
Formula Weight
429.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 20 mM
SMILES
O=C(C(O)=O)O.O=C(C1CCN(CC1)CCCCC2=CC=CC=C2)C3=CC=C(C=C3)F
InChi Code
InChI=1S/C22H26FNO.C2H2O4/c23-21-11-9-19(10-12-21)22(25)20-13-16-24(17-14-20)15-5-4-8-18-6-2-1-3-7-18;3-1(4)2(5)6/h1-3,6-7,9-12,20H,4-5,8,13-17H2;(H,3,4)(H,5,6)
InChi Key
VUJYJCRJPFMHEM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $84

    Add

    10 mg

    $142

    Add
    Product Description

    4F 4PP is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 5.3 nM).1 It is selective for 5-HT2A receptors over 5-HT1C receptors (Ki = 620 nM). It inhibits 5-HT-induced currents in Xenopus oocytes expressing human 5-HT2A receptors (IC50 = 5.15 µM).2 Spinal superfusion of 4F 4PP (100 µM) reduces the area of electrically stimulated spinal field potentials in a rat model of neuropathic pain induced by spinal nerve ligation (SNL).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Herndon, J.L., Ismaiel, A., Ingher, S.P., et al. Ketanserin analogues: Structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding. J. Med. Chem. 35(26), 4903-4910 (1992).

    2. Acuña-Castillo, C., Villalobos, C., Moya, P.R., et al. Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT2A and 5-HT2C receptors. Br. J. Pharmacol. 136(4), 510-519 (2002).

    3. Aira, Z., Buesa, I., Salgueiro, M., et al. Subtype-specific changes in 5-HT receptor-mediated modulation of C fibre-evoked spinal field potentials are triggered by peripheral nerve injury. Neuroscience 168(3), 831-841 (2010).