A 5-HT2A receptor antagonist
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4F 4PP (oxalate)

Item No. 35005

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4-fluorophenyl)[1-(4-phenylbutyl)-4-piperidinyl]-methanone, monoethanedioate
CAS Number
144734-36-1
Molecular Formula
C22H26FNO • C2H2O4
Formula Weight
429.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 20 mM
SMILES
O=C(C(O)=O)O.O=C(C1CCN(CC1)CCCCC2=CC=CC=C2)C3=CC=C(C=C3)F
InChi Code
InChI=1S/C22H26FNO.C2H2O4/c23-21-11-9-19(10-12-21)22(25)20-13-16-24(17-14-20)15-5-4-8-18-6-2-1-3-7-18;3-1(4)2(5)6/h1-3,6-7,9-12,20H,4-5,8,13-17H2;(H,3,4)(H,5,6)
InChi Key
VUJYJCRJPFMHEM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $84

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    10 mg

    $142

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    Product Description

    4F 4PP is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 5.3 nM).1 It is selective for 5-HT2A receptors over 5-HT1C receptors (Ki = 620 nM). It inhibits 5-HT-induced currents in Xenopus oocytes expressing human 5-HT2A receptors (IC50 = 5.15 µM).2 Spinal superfusion of 4F 4PP (100 µM) reduces the area of electrically stimulated spinal field potentials in a rat model of neuropathic pain induced by spinal nerve ligation (SNL).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Herndon, J.L., Ismaiel, A., Ingher, S.P., et al. Ketanserin analogues: Structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding. J. Med. Chem. 35(26), 4903-4910 (1992).

    2. Acuña-Castillo, C., Villalobos, C., Moya, P.R., et al. Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT2A and 5-HT2C receptors. Br. J. Pharmacol. 136(4), 510-519 (2002).

    3. Aira, Z., Buesa, I., Salgueiro, M., et al. Subtype-specific changes in 5-HT receptor-mediated modulation of C fibre-evoked spinal field potentials are triggered by peripheral nerve injury. Neuroscience 168(3), 831-841 (2010).