A peptide inhibitor of α4β1 integrin
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BIO-1211 (trifluoroacetate salt)

Item No. 35007

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]-L-leucyl-L-α-aspartyl-L-valyl-L-proline, trifluoroacetate salt
Molecular Formula
C36H48N6O9 • XCF3COOH
Formula Weight
708.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
258 nm
SMILES
CC(C=CC=C1)=C1NC(NC(C=C2)=CC=C2CC(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N3[C@@H](CCC3)C(O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C36H48N6O9.C2HF3O2/c1-20(2)17-26(38-29(43)18-23-12-14-24(15-13-23)37-36(51)40-25-10-7-6-9-22(25)5)32(46)39-27(19-30(44)45)33(47)41-31(21(3)4)34(48)42-16-8-11-28(42)35(49)50;3-2(4,5)1(6)7/h6-7,9-10,12-15,20-21,26-28,31H,8,11,16-19H2,1-5H3,(H,38,43)(H,39,46)(H,41,47)(H,44,45)(H,49,50)(H2,37,40,51);(H,6,7)/t26-,27-,28-,31-;/m0./s1
InChi Key
NMTAUOFQNNRBTK-LTQJSTEVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $174

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    5 mg

    $690

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    10 mg

    $1,293

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    Product Description

    BIO-1211 is a peptide inhibitor of α4β1 integrin (IC50 = 0.004 µM).1 It is selective for α4β1 integrin over α4β7 (IC50 = 2 µM), as well as α1β1, α5β1, α6β1, αLβ2, and αIIbβ3 (IC50s = >100 µM for all). BIO-1211 binds to α4β1 (IC50 = 1 nM) and inhibits Jurkat cell adhesion (IC50 = 4 nM). Inhaled administration of BIO-1211 (3 mg/animal) prevents carbachol-induced airway hyperresponsiveness in an ovine model of allergy-induced asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, K.c., Ateeq, H.S., Hsiung, S.H., et al. Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses. J. Med. Chem. 42(5), 920-934 (1999).