A voltage-gated sodium channel inhibitor and an active metabolite of eslicarbazepine acetate
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Eslicarbazepine

Item No. 35008

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(10S)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
CAS Number
104746-04-5
Synonyms
  • BIA 2-194
  • CGP 13751
  • (S)-Licarbazepine
Molecular Formula
C15H14N2O2
Formula Weight
254.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
NC(N1C2=CC=CC=C2[C@H](CC3=CC=CC=C31)O)=O
InChi Code
InChI=1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)/t14-/m0/s1
InChi Key
BMPDWHIDQYTSHX-AWEZNQCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $179

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    10 mg

    $315

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    Product Description

    Eslicarbazepine is a voltage-gated sodium channel (Nav) inhibitor and an active metabolite of the prodrug eslicarbazepine acetate (Item No. 23656).1,2 It enhances slow activation of voltage-gated sodium channels, reducing channel availability.1 Eslicarbazepine is protective against seizures induced by maximal electroshock (MES) in mice (ED50 = 17.1 mg/kg).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Soares-Da-Silva, P., Pires, N., Bonifácio, M.J., et al. Eslicarbazepine acetate for the treatment of focal epilepsy: An update on its proposed mechanisms of action. Pharmacol. Res. Perspect. 3(2), e00124 (2015).

    2. Benes, J., Parada, A., Figueiredo, A.A., et al. Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. J. Med. Chem. 42(14), 2582-2587 (1999).