Suberosin

Suberosin is a prenylated coumarin that has been found in C. articulata and has diverse biological activities.^1,2,3 It inhibits platelet aggregation induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), collagen, platelet-activating factor (PAF), adenosine 5'-diphosphate (ADP; Item No. 21121), or U-46619 (Item No. 16450) in washed isolated rabbit platelets (IC₅₀s = 60, 132, 200, 234, and 200 µM, respectively).² Suberosin (50 or 100 µM) reduces arachidonic acid-induced formation of thromboxane B₂ (TXB₂; Item No. 19030) in the same model. It inhibits NF-κB nuclear translocation induced by phytohemagglutinin (PHA) in, as well as PHA-induced proliferation of, human peripheral blood mononuclear cells (PBMCs) when used at a concentration of 100 µM.³

WARNING This product is not for human or veterinary use.

1. Paudel, S., Kim, Y., Choi, S.M., et al. Identification of suberosin metabolites in human liver microsomes by high-performance liquid chromatography combined with high-resolution quadrupole-orbitrap mass spectrometer. J. Mass Spectrom. 56(4), e4623 (2021).

2. Teng, C.M., Li, H.L., Wu, T.S., et al. Antiplatelet actions of some coumarin compounds isolated from plant sources. Thromb. Res. 66(5), 549-557 (1992).

3. Chen, Y.-C., Tsai, W.-J., Wu, M.-H., et al. Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-κB. Br. J. Pharmacol. 150(3), 298-312 (2007).