An estrogen receptor antagonist and a derivative of fulvestrant
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Fulvestrant 9-sulfone

Item No. 35070

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7α-[9-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]nonyl]-estra-1,3,5(10)-triene-3,17β-diol
CAS Number
98008-06-1
Molecular Formula
C32H47F5O4S
Formula Weight
622.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
OC1=CC=C2C(C[C@@H](CCCCCCCCCS(CCCC(F)(F)C(F)(F)F)(=O)=O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4O)=C1
InChi Code
InChI=1S/C32H47F5O4S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-42(40,41)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+/m1/s1
InChi Key
NQYWBGDKCPOMGL-LSVBPWPTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $74

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    5 mg

    $239

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    10 mg

    $403

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    25 mg

    $912

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    Product Description

    Fulvestrant 9-sulfone is an estrogen receptor antagonist and a derivative of the selective estrogen receptor degrader (SERD) fulvestrant (Item No. 10011269).1 It binds to estrogen receptor α (ERα) and ERβ and inhibits estrogen-induced gene expression in a reporter assay in Ishikawa endometrial cells expressing an estrogen response element (ERE) reporter when used at concentrations ranging from 0.1 to 100 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nuttall, M.E., Pendrak, I., Emery, J.G., et al. Antagonism of oestrogen action in human breast and endometrial cells in vitro: Potential novel antitumour agents. Cancer Chemother. Pharmacol. 47(5), 437-443 (2001).