A potential impurity found in commercial preparations of darifenacin
Related Products
Isomer(s)
278523-hydroxy Darifenacin
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Darifenacin N-oxide

Item No. 35083

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-(2,3-dihydro-5-benzofuranyl)ethyl]-α,α-diphenyl-3-pyrrolidineacetamide, 1-oxide
CAS Number
2416229-88-2
Molecular Formula
C28H30N2O3
Formula Weight
442.5
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
NC(C(C1C[N+](CCC2=CC=C(OCC3)C3=C2)([O-])CC1)(C4=CC=CC=C4)C5=CC=CC=C5)=O
InChi Code
InChI=1S/C28H30N2O3/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(32,20-25)16-13-21-11-12-26-22(19-21)15-18-33-26/h1-12,19,25H,13-18,20H2,(H2,29,31)
InChi Key
NWHZIKCUBJRZEN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $112

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    10 mg

    $202

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    Product Description

    Darifenacin N-oxide is a potential impurity found in commercial preparations of the muscarinic acetylcholine receptor (mAChR) antagonist darifenacin.1 It is a degradation product formed under oxidative conditions.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thomas, S., Paul, S.K., Shandilya, S., et al. Identification and structural elucidation of two process impurities and stress degradants in darifenacin hydrobromide active pharmaceutical ingredient by LC-ESI/MSn. Analyst 137(15), 3571-3582 (2012).