Senkyunolide H

Senkyunolide H is a phthalide that has been found in L. chuanxiong and has diverse biological activities.^1,2,3,4 It increases levels of heme oxygenase-1 (HO-1) in HepG2 cells, as well as reduces hydrogen peroxide-induced increases in reactive oxygen species (ROS) and malondialdehyde (MDA) in the same cells when used at concentrations of 150 and 200 µg/ml.² Senkyunolide H inhibits the proliferation of primary mouse aorta smooth muscle cells (IC₅₀ = <0.1 µg/ml).³ It decreases bone resorption in ovariectomized mice when administered at a dose of 15 mg/kg.⁴

WARNING This product is not for human or veterinary use.

1. Yan, R., Li, S.-L., Chung, H.-S., et al. Simultaneous quantification of 12 bioactive components of Ligusticum chuanxiong Hort. by high-performance liquid chromatography. J. Pharm. Biomed. Anal. 37(1), 87-95 (2005).

2. Qi, H., Siu, S.O., Chen, Y., et al. Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1. Chem. Biol. Interact. 183(3), 380-389 (2010).

3. Kobayashi, S., Mimura, Y., Notoya, K., et al. Antiproliferative effects of the traditional Chinese medicine shimotsu-to, its component cnidium rhizome and derived compounds on primary cultures of mouse aorta smooth muscle cells. Jpn. J. Pharmacol. 60(4), 397-401 (1992).

4. Yang, D., Liu, T., Jiang, G., et al. Senkyunolide H attenuates osteoclastogenesis and postmenopausal osteoporosis by regulating the NF-κB, JNK and ERK signaling pathways. Biochem. Biophys. Res. Commun. 533(3), 510-518 (2020).