A phthalide with diverse biological activities
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Isomer(s)
35142Senkyunolide H
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Senkyunolide I

Item No. 35649

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3Z,6R,7R)-rel-3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-1(3H)-isobenzofuranone
CAS Number
94596-28-8
Molecular Formula
C12H16O4
Formula Weight
224.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 10 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
274 nm
SMILES
O[C@H]1C2=C(CC[C@@H]1O)/C(OC2=O)=C/CCC
InChi Code
InChI=1S/C12H16O4/c1-2-3-4-9-7-5-6-8(13)11(14)10(7)12(15)16-9/h4,8,11,13-14H,2-3,5-6H2,1H3/b9-4-/t8-,11+/m0/s1
InChi Key
DQNGMIQSXNGHOA-JXQVETIVSA-N
Origin
Plant/Ligusticum chuanxiong Hort.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Senkyunolide I is a phthalide that has been found in L. chuanxiong and has diverse biological activities.1,2,3,4 It inhibits TNF-α-induced NF-κB reporter gene expression in HEK293 cells and reduces LPS-induced IL-8 and IL-6 production in THP-1 cells when used at a concentration of 100 µM.1 In vivo, senkyunolide I (32 mg/kg) reduces acetic acid-induced writhing and increases the latency to paw withdrawal in the hot plate test in mice.3 Senkyunolide I (36 mg/kg, i.p.) increases survival, decreases plasma levels of TNF-α, IL-1β, and IL-6, and protects against cognitive dysfunction in a mouse model of sepsis induced by cecal ligation and puncture (CLP).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jiang, M., Zhou, M., Han, Y., et al. Identification of NF-κB Inhibitors in Xuebijing injection for sepsis treatment based on bioactivity-integrated UPLC-Q/TOF. J. Ethnaopharmacol. 147(2), 426-433 (2013).

    2. Huang, Y., Wu, Y., Yin, H., et al. Senkyunolide I: A review of its phytochemistry, pharmacology, pharmacokinetics, and drug-likeness. Molecules 28(8), 3636 (2023).

    3. Wang, Y.-H. Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. J. Pharm. Pharmacol. 63(2), 261-266 (2010).

    4. Xie, J., Zhao, Z.-Z., Li, P., et al. Senkyunolide I protects against sepsis-associated encephalopathy by attenuating sleep deprivation in a murine model of cecal ligation and puncture. Oxid. Med. Cell. Longev. 6647258 (2021).