A laminin α1-derived peptide
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

SIKVAV (acetate)

Item No. 35159

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-seryl-L-isoleucyl-L-lysyl-L-valyl-L-alanyl-L-valine, acetate
Synonyms
  • Hexapeptide-10
  • Ser-Ile-Lys-Val-Ala-Val
Molecular Formula
C28H53N7O8 • XC2H4O2
Formula Weight
615.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 2 mg/ml
SMILES
OC[C@H](N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O.CC(O)=O
InChi Code
InChI=1S/C28H53N7O8.C2H4O2/c1-8-16(6)22(35-24(38)18(30)13-36)27(41)32-19(11-9-10-12-29)25(39)33-20(14(2)3)26(40)31-17(7)23(37)34-21(15(4)5)28(42)43;1-2(3)4/h14-22,36H,8-13,29-30H2,1-7H3,(H,31,40)(H,32,41)(H,33,39)(H,34,37)(H,35,38)(H,42,43);1H3,(H,3,4)/t16-,17-,18-,19-,20-,21-,22-;/m0./s1
InChi Key
FIFWXXZWRVLXSE-NRKABSNUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $49

    Add

    500 mg

    $213

    Add

    1 g

    $376

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    SIKVAV is a laminin α1-derived peptide.1 It binds to α3, α6, and β1 integrins and induces adhesion of CAC2 adenoid cystic carcinoma cells when used at a concentration of 1 µg/ml. SIKVAV (100 µg/ml) stimulates the proliferation and migration of primary mouse fibroblasts, as well as induces the secretion of EGF, VEGF, TGF-β, and FGF in the same cells.2 Topical administration of a chitosan hydrogel containing SIKVAV promotes wound healing and angiogenesis in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Freitas, V.M., Vilas-Boas, V.F., Pimenta, D.C., et al. SIKVAV, a laminin α1-derived peptide, interacts with integrins and increases protease activity of a human salivary gland adenoid cystic carcinoma cell line through the ERK ½ signaling pathway. Am. J. Pathol. 171(1), 124-138 (2007).

    2. Chen, X., Zhang, M., Chen, S., et al. Peptide-modified chitosan hydrogels accelerate skin wound healing by promoting fibroblast proliferation, migration, and secretion. Cell Transplant. 26(8), 1331-1340 (2017).