A peptide derivative of enkephalin
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Isomer(s)
28928DADLE
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Product Categories

Product Type

Biochemicals
Peptides

Research Area

Neuroscience
Pain Research

Pentapeptide-18 (acetate)

Item No. 35198

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucine, acetate
Synonyms
  • [Ala2,Leu5]-Enkephalin
  • [D-Ala2]Leucine-Enkephalin
  • Tyr-D-Ala-Gly-Phe-Leu-OH
Molecular Formula
C29H39N5O7 • XC2H4O2
Formula Weight
569.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
CC(C)C[C@@H](C(O)=O)NC([C@@H](NC(CNC([C@@H](C)NC([C@@H](N)CC1=CC=C(C=C1)O)=O)=O)=O)CC2=CC=CC=C2)=O.CC(O)=O
InChi Code
InChI=1S/C29H39N5O7.C2H4O2/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20;1-2(3)4/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41);1H3,(H,3,4)/t18-,22+,23+,24+;/m1./s1
InChi Key
YRZBXSPTRALQEX-KBUZRCILSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $103

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    10 mg

    $193

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    25 mg

    $454

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    50 mg

    $853

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    Product Description

    Pentapeptide-18 is a peptide derivative of enkephalin.1,2 It reduces tail pinch-induced hyperalgesia in rats.2 Formulations containing pentapeptide-18 have been used in cosmeceuticals.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Beddell, C.R., Clark, R.B., Hardy, G.W., et al. Structural requirements for opioid activity of analogues of the enkephalins. Proc. R. Soc. Long. B. Biol. Sci. 198(1132), 249-265 (1977).

    2. Maeda, M., Kawasaki, K., Mayumi, T., et al. Amino acids and peptides. XXII. Preparation and antinociceptive effect of [D-Ala2]Leu-enkephalin-poly(ethylene glycol) hybrid. Biol. Pharm. Bull. 17(6), 823-825 (1994).