An antagonist of NPY receptor Y1
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BIBO-3304 (trifluoroacetate salt)

Item No. 35205

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1R)-1-[[[[4-[[(aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamide, trifluoroacetate salt
CAS Number
191868-14-1
Molecular Formula
C29H35N7O3 • CF3COOH
Formula Weight
643.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
OC(C(F)(F)F)=O.NC(NCC(C=C1)=CC=C1CNC([C@@H](CCCNC(N)=N)NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)=O)=O
InChi Code
InChI=1S/C29H35N7O3.C2HF3O2/c30-28(31)33-17-7-12-24(26(37)34-18-20-13-15-21(16-14-20)19-35-29(32)39)36-27(38)25(22-8-3-1-4-9-22)23-10-5-2-6-11-23;3-2(4,5)1(6)7/h1-6,8-11,13-16,24-25H,7,12,17-19H2,(H,34,37)(H,36,38)(H4,30,31,33)(H3,32,35,39);(H,6,7)/t24-;/m1./s1
InChi Key
FBMCYYWIBYEOST-GJFSDDNBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

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    10 mg

    $376

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    25 mg

    $820

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    Product Description

    BIBO-3304 is an antagonist of the neuropeptide Y (NPY) receptor Y1 (Kis = 0.38 and 0.72 nM, respectively).1 It is selective for Y1 over Y2, Y4, and Y5 receptors (Kis = >1,000 nM for all). BIBO-3304 (30 µg/animal) inhibits NPY-induced increases in food intake in fasted rats when injected into the paraventricular nucleus (PVN) of the hypothalamus. It also inhibits the pressor response induced by NPY or bilateral common carotid artery occlusion in cats when administered at a dose of 100 µg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wieland, H.A., Engel, W., Eberlein, W., et al. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br. J. Pharmacol. 125(3), 549-555 (1998).

    2. Capurro, D., and Huidobro-Toro, J.P. The involvement of neuropeptide Y Y1 receptors in the blood pressure baroreflex: Studies with BIBP 3226 and BIBO 3304. Eur. J. Pharmacol. 376(3), 251-255 (1999).