An internal standard for the quantification of metanephrine
Related Products
Unlabeled Version(s)
15408Metanephrine
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Metanephrine-d3 (hydrochloride)

Item No. 35207

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-3-methoxy-α-[(methyl-d3-amino)methyl]-benzenemethanol, monohydrochloride
CAS Number
1215507-88-2
Synonyms
  • DL-Metanephrine-d3
Molecular Formula
C10H12D3NO3 • HCl
Formula Weight
236.7
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 15 mg/ml
SMILES
[2H]C([2H])([2H])NCC(C1=CC(OC)=C(C=C1)O)O.Cl
InChi Code
InChI=1S/C10H15NO3.ClH/c1-11-6-9(13)7-3-4-8(12)10(5-7)14-2;/h3-5,9,11-13H,6H2,1-2H3;1H/i1D3;
InChi Key
HRIQFVCFOPJYEQ-NIIDSAIPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $121

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    5 mg

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    Product Description

    Metanephrine-d3 is intended for use as an internal standard for the quantification of metanephrine (Item No. 15408) by GC- or LC-MS. Metanephrine is an inactive metabolite of epinephrine (Item No. 21245).1 It is formed from epinephrine by catechol-O-methyl transferase (COMT).2 Urinary and plasma levels of metanephrine are increased in patients with pheochromocytoma, an adrenal medullary neuroendocrine tumor.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bilezikian, J.P., Dornfeld, A.M., and Gammon, D.E. Structure-binding-activity analysis of beta-adrenergic amines—I. Binding to the beta receptor and activation of adenylate cyclase. Biochem. Pharmacol. 27(10), 1445-1454 (1978).

    2. Kopin, I.J., Axelrod, J., and Gordon, E. The metabolic fate of H3-epinephrine and C14-metanephrine in the rat. The Journal of Biological Chemisty 236(7), 2109-2136 (1961).

    3. Wolthers, B.G., Kema, I.P., Volmer, M., et al. Evaluation of urinary metanephrine and normetanephrine enzyme immunoassay (ELISA) kits by comparison with isotope dilution mass spectrometry. Clin. Chem. 43, 114-120 (1997).

    4. Goldstein, D.S., Eisenhofer, G., and Kopin, I.J. Sources and significance of plasma levels of catechols and their metabolites in humans. J. Pharm. Exp. Ther. 305(3), 800-811 (2003).