An inactive metabolite of epinephrine
Related Products
Isomer(s)
35608Desglymidodrine
Labeled Version(s)
35207Metanephrine-d3 (hydrochloride)
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Metanephrine

Item No. 15408

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-3-methoxy-α-[(methylamino)methyl]-benzenemethanol
CAS Number
5001-33-2
Synonyms
  • DL-Metanephrine
Molecular Formula
C10H15NO3
Formula Weight
197.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 15 mg/ml
λmax
229, 279 nm
SMILES
COC1=C(O)C=CC(C(O)CNC)=C1
InChi Code
InChI=1S/C10H15NO3/c1-11-6-9(13)7-3-4-8(12)10(5-7)14-2/h3-5,9,11-13H,6H2,1-2H3
InChi Key
JWJCTZKFYGDABJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $69

    Add

    10 mg

    $115

    Add

    50 mg

    $363

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Metanephrine is an inactive metabolite of epinephrine (Item No. 21245).1 It is formed from epinephrine by catechol-O-methyl transferase (COMT).2 Urinary and plasma levels of metanephrine are increased in patients with pheochromocytoma, an adrenal medullary neuroendocrine tumor.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bilezikian, J.P., Dornfeld, A.M., and Gammon, D.E. Structure-binding-activity analysis of beta-adrenergic amines—I. Binding to the beta receptor and activation of adenylate cyclase. Biochem. Pharmacol. 27(10), 1445-1454 (1978).

    2. Kopin, I.J., Axelrod, J., and Gordon, E. The metabolic fate of H3-epinephrine and C14-metanephrine in the rat. The Journal of Biological Chemisty 236(7), 2109-2136 (1961).

    3. Wolthers, B.G., Kema, I.P., Volmer, M., et al. Evaluation of urinary metanephrine and normetanephrine enzyme immunoassay (ELISA) kits by comparison with isotope dilution mass spectrometry. Clin. Chem. 43, 114-120 (1997).

    4. Goldstein, D.S., Eisenhofer, G., and Kopin, I.J. Sources and significance of plasma levels of catechols and their metabolites in humans. J. Pharm. Exp. Ther. 305(3), 800-811 (2003).