A glycoside with anti-inflammatory and immune regulatory activities
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Isomer(s)
39839Rosavin
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Rosarin

Item No. 35214

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-3-phenyl-2-propen-1-yl 6-O-α-L-arabinofuranosyl-β-D-glucopyranoside
CAS Number
84954-93-8
Molecular Formula
C20H28O10
Formula Weight
428.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
251 nm
SMILES
O[C@H]([C@H]([C@@H]1O)O)[C@H](OC/C=C/C2=CC=CC=C2)O[C@@H]1CO[C@H]3[C@H](O)[C@@H](O)[C@H](CO)O3
InChi Code
InChI=1S/C20H28O10/c21-9-12-14(22)17(25)20(29-12)28-10-13-15(23)16(24)18(26)19(30-13)27-8-4-7-11-5-2-1-3-6-11/h1-7,12-26H,8-10H2/b7-4+/t12-,13+,14-,15+,16-,17+,18+,19+,20+/m0/s1
InChi Key
IEBFEMIXXHIISM-YZOUKVLTSA-N
Origin
Plant/Rhodiola rosea
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $48

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    5 mg

    $206

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    10 mg

    $366

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    Product Description

    Rosarin is a glycoside that has been found in R. rosea and has anti-inflammatory and immune regulatory activities.1 It prevents LPS-induced increases in induced nitric oxide synthase (iNOS), TNF-α, IL-1β, and IL-6 levels in BV-2 microglia when used at concentrations of 10 and 50 µg/ml. Rosarin reduces LPS-induced nitric oxide (NO) production in BV-2 microglia. It inhibits the growth of Jurkat T cells induced by concanavalin A (Item No. 14951) or anti-CD3 and anti-CD28 antibodies (IC50s = 60 and 68 µM, respectively) and increases TRAIL levels in isolated mouse splenic T cells when used at concentrations of 0.5, 5, and 50 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, Y., Jung, J.-C., Jang, S., et al. Anti-inflammatory and neuroprotective effects of constituents isolated from Rhodiola rosea. Evid. Based Complement. Alternat. Med. 514049 (2013).

    2. Marchev, A.S., Dimitrova, P., Koycheva, I.K., et al. Altered expression of TRAIL on mouse T cells via ERK phosphorylation by Rhodiola rosea L. and its marker compounds. Food Chem. Toxicol. 108(Pt B), 419-428 (2017).