A catabolite of cytidine
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N4-Acetylcytidine

Item No. 35219

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-cytidine
CAS Number
3768-18-1
Synonyms
  • ac4C
Molecular Formula
C11H15N3O6
Formula Weight
285.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
215, 247, 299 nm
SMILES
O[C@H]1[C@@](N2C(N=C(C=C2)NC(C)=O)=O)([H])O[C@H](CO)[C@H]1O
InChi Code
InChI=1S/C11H15N3O6/c1-5(16)12-7-2-3-14(11(19)13-7)10-9(18)8(17)6(4-15)20-10/h2-3,6,8-10,15,17-18H,4H2,1H3,(H,12,13,16,19)/t6-,8-,9-,10-/m1/s1
InChi Key
NIDVTARKFBZMOT-PEBGCTIMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    N4-Acetylcytidine is a catabolite of cytidine.1 It activates BV-2 microglia when used at a concentration of 0.3 mM, an effect that can be blocked by the adenosine A2A receptor antagonist SCH 58261 (Item No. 19676).2 It also increases protein levels of the NOD-like receptor protein 3 (NLRP3) inflammasome, an effect that can be blocked by high mobility group box 1 (HMGB1) siRNA in BV-2 microglia. Urine levels of N4-acetylcytidine are increased in mice with tumors induced by 3-methylcholanthrene.1 N4-Acetylcytidine is also found as a post-transcriptional modification in RNA.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thomale, J., and Nass, G. Elevated urinary excretion of RNA catabolites as an early signal of tumor development in mice. Cancer Lett. 15(2), 149-159 (1982).

    2. Duan, J.J., Zhang, Q., Hu, X., et al. N4-acetylcytidine is required for sustained NLRP3 inflammasome activation via HMGB1 pathway in microglia. Cell. Signal. 58, 44-52 (2019).

    3. Bartee, D., Nance, K.D., and Meier, J.L. Site-specific synthesis of N4-acetylcytidine in RNA reveals physiological duplex stabilization. J. Am. Chem. Soc. 144(8), 3487-3496 (2022).