A triple monoamine reuptake inhibitor
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Tesofensine

Item No. 35224

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane
CAS Number
195875-84-4
Synonyms
  • NS 2330
Molecular Formula
C17H23Cl2NO
Formula Weight
328.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mLDMSO: 1 mg/mLEthanol: Slightly solublePBS (pH 7.2): 0.14 mg/mL
SMILES
CN1[C@@H]2C[C@H](C3=CC(Cl)=C(Cl)C=C3)[C@@H](COCC)[C@H]1CC2
InChi Code
InChI=1S/C17H23Cl2NO/c1-3-21-10-14-13(9-12-5-7-17(14)20(12)2)11-4-6-15(18)16(19)8-11/h4,6,8,12-14,17H,3,5,7,9-10H2,1-2H3/t12-,13+,14+,17+/m0/s1
InChi Key
VCVWXKKWDOJNIT-ZOMKSWQUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $252

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    10 mg

    $379

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    50 mg

    $883

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    100 mg

    $1,638

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    Cayman Chemical
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    Product Description

    Tesofensine is a triple monoamine reuptake inhibitor that inhibits norepinephrine, serotonin (5-HT), and dopamine reuptake function.1,2 In vivo, tesofensine (2 mg/kg, s.c.) reduces body weight and food intake in a rat model of high-fat diet-induced obesity.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Axel, A., M,D., Mikkelsen, J.D., and Hansen, H.H. Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of α1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat. Neuropsychopharmacology 35(7), 1464-1476 (2010).

    2. van de Giessen, E., de Bruin, K., la Fleur, S.E., et al. Triple monoamine inhibitor tesofensine decreases food intake, body weight, and striatal dopamine D2/D3 receptor availability in diet-induced obese rats. Eur. Neuropsychopharmacol. 22(4), 290-299 (2012).