A synthetic flavonoid with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

3',4'-Dihydroxyflavone

Item No. 35226

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one
CAS Number
4143-64-0
Synonyms
  • 3',4'-DHF
Molecular Formula
C15H10O4
Formula Weight
254.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 10 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.16 mg/ml
λmax
245, 345 nm
SMILES
O=C1C=C(C2=CC(O)=C(O)C=C2)OC3=CC=CC=C13
InChi Code
InChI=1S/C15H10O4/c16-11-6-5-9(7-13(11)18)15-8-12(17)10-3-1-2-4-14(10)19-15/h1-8,16,18H
InChi Key
SRNPMQHYWVKBAV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $44

    Add

    100 mg

    $80

    Add

    250 mg

    $174

    Add

    500 mg

    $304

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    3',4'-Dihydroxyflavone is a synthetic flavonoid that has diverse biological activities.1,2,3,4 It inhibits tankyrase 1 (TNKS1) and TNKS2 (IC50s = 0.23 and 0.17 µM for the human enzymes, respectively).1 3',4'-Dihydroxyflavone is active against L. donovani, T. brucei, and T. cruzi with IC50 values of 2, 1.1, and 10.1 µg/ml, respectively.2 It induces apoptosis in and inhibits migration of GL15 glioblastoma cells when used at a concentration of 50 µM.3 3',4'-Dihydroxyflavone (5 mg/kg) prevents LPS-induced increases in brain levels of COX-2 and inducible nitric oxide synthase (iNOS) in a mouse model of neuroinflammation.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Narwal, M., Koivunen, J., Haikarainen, T., et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J. Med. Chem. 56(20), 7880-7889 (2013).

    2. Tasdemir, D., Kaiser, M., Brun, R., et al. Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: In vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. Antimicrob. Agents Chemother. 50(4), 1352-1364 (2006).

    3. Santos, B.L., Oliveira, M.N., Coelho, P.L.C., et al. Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression. Chem. Biol. Interact. 242, 123-138 (2015).

    4. Kim, N., Yoo, H.-S., Ju, Y.-J., et al. Synthetic 3',4'-dihydroxyflavone exerts anti-neuroinflammatory effects in BV2 microglia and a mouse model. Biomol. Ther. (Seoul) 26(2), 210-217 (2018).