A flavonoid with diverse biological activities
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7,4'-Dihydroxyflavone

Item No. 35491

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CAS Number
2196-14-7
Synonyms
  • 7,4'-DHF
Molecular Formula
C15H10O4
Formula Weight
254.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/ml
λmax
330 nm
SMILES
O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=CC=C13
InChi Code
InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-8,16-17H
InChi Key
LCAWNFIFMLXZPQ-UHFFFAOYSA-N
Origin
Plant/Unidentified sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $60

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    1 g

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    5 g

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    Cayman Chemical
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    Product Description

    7,4’-Dihydroxyflavone (7,4'-DHF) is a flavonoid that has been found in G. uralensis and has diverse biological activities.1,2,3 It inhibits the activity of rat lens aldose reductase (IC50 = 3.8 µM).1 7,4'-DHF is active against L. donovani amastigotes and T. b. rhodesiense, but not T. cruzi, trypomastigotes (IC50s = 11.1, 6.9, and >30 µg/ml, respectively).2 It scavenges DPPH (Item No. 14805) radicals when used at a concentration of 15 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matsuda, H., Morikawa, T., Toguchida, I., et al. Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity. Chem. Pharm. Bull. (Tokyo) 50(6), 788-795 (2002).

    2. Tasdemir, D., Kaiser, M., Brun, R., et al. Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: In vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. Antimicrob. Agents Chemother. 50(4), 1352-1364 (2006).

    3. Cotelle, N., Bernier, J.-L., Catteau, J.-P., et al. Antioxidant properties of hydroxy-flavones. Free Radic. Biol. Med. 20(1), 35-43 (1996).