An inhibitor of SOD1
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Isomer(s)
44749EcDsbB-IN-9
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LCS-1

Item No. 35231

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone
CAS Number
41931-13-9
Synonyms
  • Lung Cancer Screen 1
Molecular Formula
C11H8Cl2N2O
Formula Weight
255.1
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 3 mg/mlEthanol: insolPBS (pH 7.2): insol
SMILES
O=C1C(Cl)=C(C=NN1C2=CC(C)=CC=C2)Cl
InChi Code
InChI=1S/C11H8Cl2N2O/c1-7-3-2-4-8(5-7)15-11(16)10(13)9(12)6-14-15/h2-6H,1H3
InChi Key
SYUPLLHVMCLXEM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $53

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    10 mg

    $95

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    25 mg

    $212

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    50 mg

    $370

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    Cayman Chemical
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    Product Description

    LCS-1 is an inhibitor of superoxide dismutase 1 (SOD1; IC50 = 1.07 µM).1 It inhibits the proliferation of NCI H358 non-small cell lung cancer (NSCLC) cells, an effect that can be decreased by overexpression of SOD1 (IC50 = 0.8 and 3.5 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Somwar, R., Erdjument-Bromage, H., Larsson, E., et al. Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. Proc. Natl. Acad. Sci. USA 108(39), 16375-16380 (2011).