An inhibitor of SOD1
Related Products
Isomer(s)
44749EcDsbB-IN-9
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

LCS-1

Item No. 35231

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone
CAS Number
41931-13-9
Synonyms
  • Lung Cancer Screen 1
Molecular Formula
C11H8Cl2N2O
Formula Weight
255.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 3 mg/mlEthanol: insolPBS (pH 7.2): insol
SMILES
O=C1C(Cl)=C(C=NN1C2=CC(C)=CC=C2)Cl
InChi Code
InChI=1S/C11H8Cl2N2O/c1-7-3-2-4-8(5-7)15-11(16)10(13)9(12)6-14-15/h2-6H,1H3
InChi Key
SYUPLLHVMCLXEM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $53

    Add

    10 mg

    $95

    Add

    25 mg

    $212

    Add

    50 mg

    $370

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    LCS-1 is an inhibitor of superoxide dismutase 1 (SOD1; IC50 = 1.07 µM).1 It inhibits the proliferation of NCI H358 non-small cell lung cancer (NSCLC) cells, an effect that can be decreased by overexpression of SOD1 (IC50 = 0.8 and 3.5 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Somwar, R., Erdjument-Bromage, H., Larsson, E., et al. Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. Proc. Natl. Acad. Sci. USA 108(39), 16375-16380 (2011).