A corticosteroid metabolite of 11-keto progesterone
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Isomer(s)
3290711-Dehydrocorticosterone
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21-Deoxycortisone

Item No. 35236

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
17-hydroxy-pregn-4-ene-3,11,20-trione
CAS Number
1882-82-2
Synonyms
  • 21-Desoxycortisone
  • NSC 38722
Molecular Formula
C21H28O4
Formula Weight
344.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlEthanol: insolPBS (pH 7.2): insol
λmax
238 nm
SMILES
C[C@@]12[C@](CC[C@]2(O)C(C)=O)([H])[C@@]3([H])[C@@](C(C1)=O)([H])[C@@]4(C(CC3)=CC(CC4)=O)C
InChi Code
InChI=1S/C21H28O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-16,18,25H,4-9,11H2,1-3H3/t15-,16-,18+,19-,20-,21-/m0/s1
InChi Key
PUKLDDOGISCFCP-JSQCKWNTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    21-Deoxycortisone is a corticosteroid metabolite of 11-keto progesterone.1 It is formed from 11-keto progesterone by the cytochrome P450 (CYP) isoform CYP17A1, but can also be produced via oxidation of 21-deoxycortisol (Item No. 30873) by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). Levels of 21-deoxycortisone are increased in patients with congenital adrenal hyperplasia, an inborn error of metabolism characterized by a deficiency in 21-hydroxylase.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. van Rooyen, D., Yadav, R., Scott, E.E., et al. CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway. J. Steroid Biochem. Mol. Biol. 199, 105614 (2020).

    2. Saisho, S., Shimozawa, K., and Yata, J. Changes of several adrenal Δ4-steroids measured by HPLC-UV spectrometry in neonatal patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Horm. Res. 33(1), 27-34 (1990).