An endogenous mineralocorticoid
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Isomer(s)
3523621-Deoxycortisone
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11-Dehydrocorticosterone

Item No. 32907

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
21-hydroxy-pregn-4-ene-3,11,20-trione
CAS Number
72-23-1
Synonyms
  • 11-DHC
  • DHCS
  • Kendall's Compound A
  • NSC 9702
Molecular Formula
C21H28O4
Formula Weight
344.4
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLEthanol: 5 mg/mL
SMILES
C[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@](CC3=O)([C@H](CC4)C(CO)=O)C
InChi Code
InChI=1S/C21H28O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-16,19,22H,3-8,10-11H2,1-2H3/t14-,15-,16+,19+,20-,21-/m0/s1
InChi Key
FUFLCEKSBBHCMO-KJQYFISQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    11-Dehydrocorticosterone is an endogenous mineralocorticoid.1,2,3 It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration-dependent manner.1,2 11-Dehydrocorticosterone decreases the sodium/creatine ratio and increases the potassium/creatine ratio in rat urine in a dose-dependent manner in a model of 11β-hydroxysteroid dehydrogenase inhibition induced by carbenoxolone (Item No. 18240).3 Chronic administration 11-dehydrocorticosterone increases plasma glucocorticoids levels, body weight gain, and adiposity, as well as induces insulin resistance in mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Muto, S., Nemoto, J., Ebata, S., et al. Corticosterone and 11-dehydrocorticosterone stimulate Na,K-ATPase gene expression in vascular smooth muscle cells. Kidney Int. 54(2), 492-508 (1998).

    2. Brem, A.S., Matheson, K.L., Barnes, J.L., et al. 11-Dehydrocorticosterone, a glucocorticoid metabolite, inhibits aldosterone action in toad bladder. Am. J. Physiol. 261(5), F873-F879 (1991).

    3. Souness, G.W., and Morris, D.J. 11-Dehydrocorticosterone in the presence of carbenoxolone is a more potent sodium retainer than corticosterone. Steroids 58(1), 24-28 (1993).

    4. Harno, E., Cottrell, E.C., Keevil, B.G., et al. 11-Dehydrocorticosterone causes metabolic syndrome, which is prevented when 11β-HSD1 is knocked out in livers of male mice. Endocrinology 154(10), 3599-3609 (2013).