An active metabolite of colchicine
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Parent Compound(s)
9000760Colchicine
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3-demethyl Colchicine

Item No. 35238

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(7S)-5,6,7,9-tetrahydro-3-hydroxy-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-acetamide
CAS Number
7336-33-6
Synonyms
  • (–)-3-Demethylcolchicine
Molecular Formula
C21H23NO6
Formula Weight
385.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: soluble
λmax
242, 352 nm
SMILES
COC1=C2C(C([C@H](CCC2=CC(O)=C1OC)NC(C)=O)=C3)=CC=C(OC)C3=O
InChi Code
InChI=1S/C21H23NO6/c1-11(23)22-15-7-5-12-9-17(25)20(27-3)21(28-4)19(12)13-6-8-18(26-2)16(24)10-14(13)15/h6,8-10,15,25H,5,7H2,1-4H3,(H,22,23)/t15-/m0/s1
InChi Key
JRRUSQGIRBEMRN-HNNXBMFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

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    50 mg

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    100 mg

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    Product Description

    3-demethyl Colchicine is an active metabolite of colchicine (Item No. 9000760).1,2 It suppresses antibody production induced by sheep red blood cells in co-culture with isolated mouse spleen cells when used at concentrations ranging from 0.1 to 10 µg/ml.2 3-demethyl Colchicine (100 µg/animal) inhibits carrageenan-induced paw edema in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schönharting, M., Mende, G., and Siebert, G. Metabolic transformation of colchicine. II. The metabolism of colchicine by mammalian liver microsomes. Hoppe Seylers Z. Physiol. Chem. 355(11), 1391-1399 (1974).

    2. Sterzl, J., Santavý, F., Sedmera, P., et al. Effect of colchicine derivatives on the antibody response induced in vitro. Folia Microbiol. (Praha) 27(4), 256-266 (1982).

    3. Sugio, K., Maruyama, M., Tsurufuji, S., et al. Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners. Life Sci. 40(1), 35-39 (1987).