A glucocorticoid
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Isomer(s)
23945Desoximetasone
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Fluocortolone

Item No. 35246

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6α-fluoro-11β,21-dihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione
CAS Number
152-97-6
Synonyms
  • SH 742
Molecular Formula
C22H29FO4
Formula Weight
376.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleMethanol: SolubleWater: Soluble
SMILES
C[C@@]12[C@](C[C@H]([C@@H]2C(CO)=O)C)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4(C([C@H](C3)F)=CC(C=C4)=O)C
InChi Code
InChI=1S/C22H29FO4/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-21(15,2)20(13)17(26)9-22(14,3)19(11)18(27)10-24/h4-5,7,11,13-14,16-17,19-20,24,26H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20-,21+,22+/m1/s1
InChi Key
GAKMQHDJQHZUTJ-ULHLPKEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $909

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    Product Description

    Fluocortolone is a glucocorticoid.1,2 It inhibits progesterone 3α-hydroxysteroid dehydrogenase in rat cortical homogenates (IC50 = 40 µM).1 Fluocortolone (3, 6, and 12 mg/kg) decreases adjuvant-induced paw edema in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stürenburg, H.J., Fries, U., and Kunze, K. Glucocorticoids and anabolic/androgenic steroids inhibit the synthesis of GABAergic steroids in rat cortex. Neuropsychobiology 35(3), 143-146 (1997).

    2. Bhargava, A.S. Effect of anti-inflammatory agents on adjuvant-induced edema modified for primary test. Pharmacol. Res. Commun. 3(1), 83-91 (1971).