A stimulator of soluble guanylyl cyclase
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Vericiguat

Item No. 35253

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-carbamic acid, methyl ester
CAS Number
1350653-20-1
Synonyms
  • BAY-1021189
  • MK-1242
Molecular Formula
C19H16F2N8O2
Formula Weight
426.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/ml
λmax
257 nm
SMILES
O=C(NC1=C(N)N=C(C2=NN(CC3=C(F)C=CC=C3)C4=C2C=C(F)C=N4)N=C1N)OC
InChi Code
InChI=1S/C19H16F2N8O2/c1-31-19(30)25-14-15(22)26-17(27-16(14)23)13-11-6-10(20)7-24-18(11)29(28-13)8-9-4-2-3-5-12(9)21/h2-7H,8H2,1H3,(H,25,30)(H4,22,23,26,27)
InChi Key
QZFHIXARHDBPBY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $73

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    10 mg

    $117

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    25 mg

    $270

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    50 mg

    $502

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    Product Description

    Vericiguat is a stimulator of soluble guanylyl cyclase (sGC).1 It stimulates the formation of cGMP in CHO cells expressing recombinant rat sGC in the absence and presence of the nitric oxide (NO) donor SNAP (Item No. 82250; EC50s = 1,005 and 39 nM, respectively), an effect that can be reversed by the sGC inhibitor ODQ (Item No. 81410). Vericiguat inhibits phenylephrine-induced contractions in isolated rabbit saphenous artery rings, rabbit aortic rings, and canine femoral vein rings (IC50s = 798, 692, and 3,072 nM, respectively), as well as decreases the coronary perfusion pressure in isolated perfused rat hearts in a concentration-dependent manner. It decreases proteinuria and increases survival in rats expressing mouse renin ((mRenR2)27), a transgenic model for hypertension, when administered at doses of 3 or 10 mg/kg. Formulations containing vericiguat have been used in the treatment of heart failure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Follmann, M., Ackerstaff, J., Redlich, G., et al. Discovery of the soluble guanylate cyclase stimulator vericiguat (BAY 1021189) for the treatment of chronic heart failure. J. Med. Chem. 60(12), 5146-5161 (2017).