A GPR18 antagonist
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PSB-CB5

Item No. 35279

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2Z)-2-[[3-[(4-chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3(2H)-one
CAS Number
1627710-30-8
Synonyms
  • CID-85469571
Molecular Formula
C20H17ClN2O2S
Formula Weight
384.9
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: up to 25 mg/ml
λmax
220, 251, 378 nm
SMILES
O=C1N2C(SCCC2)=N/C1=C\C3=CC(OCC4=CC=C(C=C4)Cl)=CC=C3
InChi Code
InChI=1S/C20H17ClN2O2S/c21-16-7-5-14(6-8-16)13-25-17-4-1-3-15(11-17)12-18-19(24)23-9-2-10-26-20(23)22-18/h1,3-8,11-12H,2,9-10,13H2/b18-12-
InChi Key
XJBQRMOGMULGPP-PDGQHHTCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $85

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    10 mg

    $161

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    25 mg

    $337

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    Product Description

    PSB-CB5 is an antagonist of G protein-coupled receptor GPR18 (IC50 = 0.279 µM).1 It is 36-, 36-, and 14-fold selective for GPR18 over GPR55, cannabinoid 1 (CB1), and CB2 receptors, respectively. PSB-CB5 (1 µM) inhibits acrosomal exocytosis induced by the endogenous GPR18 ligand arachidonoyl glycine (NAGly; Item No. 90051) in human spermatozoa.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rempel, V., Atzler, K., Behrenswerth, A., et al. Bicyclic imidazole-4-one derivatives: A new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55. Med. Chem. Commun. 5, 632-649 (2014).

    2. Flegl, C., Vogel, F., Hofreuter, A., et al. Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Sci Rep. 6, 32255 (2016).