A prenylated coumarin with anti-inflammatory and neuroprotective activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

7-Demethylsuberosin

Item No. 35282

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-hydroxy-6-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-2-one
CAS Number
21422-04-8
Synonyms
  • Demethylsuberosin
Molecular Formula
C14H14O3
Formula Weight
230.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 250 mg/ml
λmax
333 nm
SMILES
O=C1OC2=CC(O)=C(C/C=C(C)\C)C=C2C=C1
InChi Code
InChI=1S/C14H14O3/c1-9(2)3-4-10-7-11-5-6-14(16)17-13(11)8-12(10)15/h3,5-8,15H,4H2,1-2H3
InChi Key
FIDUIAPDSKSUGO-UHFFFAOYSA-N
Origin
Plant/Angelica dahurica
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $98

    Add

    10 mg

    $119

    Add

    25 mg

    $246

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    7-Demethylsuberosin is a prenylated coumarin that has been found in Angelica tenuissima and has anti-inflammatory and neuroprotective activities.1,2 It inhibits histamine release induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) and A23187 (Item No. 11016) from HMC-1 human mast cell leukemia cells when used at a concentration of 10 µM.1 7-Demethylsuberosin (0.1-10 µM) protects against glutamate-induced cytotoxicity in primary rat cortical cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Choi, H.G., Je, I.-G., Kim, G.J., et al. Chemical constituents of the root of Angelica tenuissima and their anti-allergic inflammatory activity. Nat. Prod. Commun. 12(5), 779-780 (2017).

    2. Kang, S.Y., and Kim, Y.C. Neuroprotective coumarins from the root of Angelica gigas: Structure-activity relationships. Arch. Pharm. Res. 30(11), 1368-1373 (2007).