A peptide fragment of Nogo-A
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Nogo-66 (1-40) (human, mouse, rat) (trifluoroacetate salt)

Item No. 35310

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-acetyl-L-arginyl-L-isoleucyl-L-tyrosyl-L-lysylglycyl-L-valyl-L-isoleucyl-L-glutaminyl-L-alanyl-L-isoleucyl-L-glutaminyl-L-lysyl-L-seryl-L-α-aspartyl-L-α-glutamylglycyl-L-histidyl-L-prolyl-L-phenylalanyl-L-arginyl-L-alanyl-L-tyrosyl-L-leucyl-L-α-glutamyl-L-seryl-L-α-glutamyl-L-valyl-L-alanyl-L-isoleucyl-L-seryl-L-α-glutamyl-L-α-glutamyl-L-leucyl-L-valyl-L-glutaminyl-L-lysyl-L-tyrosyl-L-seryl-L-asparaginyl-L-serinamide, monotrifluoroacetate salt
Synonyms
  • NEP1-40
  • Nogo-40
  • Nogo-A Inhibitory Peptide
  • RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
Molecular Formula
C206H324N56O65 • CF3COOH
Formula Weight
4739.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1mg/mL
SMILES
OC(C[C@H](NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@](NC([C@H](C(C)C)NC(CNC([C@H](CCCCN)NC([C@H](CC(C=C1)=CC=C1O)NC([C@](NC([C@H](CCCNC(N)=N)NC(C)=O)=O)([H])[C@H](CC)C)=O)=O)=O)=O)=O)([H])[C@H](CC)C)=O)=O)C)=O)([H])[C@H](CC)C)=O)=O)=O)=O)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC2=CNC=N2)C(N3CCC[C@H]3C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CC(C=C4)=CC=C4O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@](C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C=C5)=CC=C5O)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)([H])[C@H](CC)C)=O)C)=O)=O)=O)=O)=O)CC(C)C)=O)=O)C)=O)=O)CC6=CC=CC=C6)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C206H324N56O65.C2HF3O2/c1-23-104(15)163(258-169(292)109(20)226-174(297)126(59-67-148(210)272)240-201(324)166(107(18)26-4)261-199(322)160(101(9)10)255-153(277)92-223-171(294)120(41-30-33-75-207)230-186(309)138(86-115-51-57-119(271)58-52-115)249-202(325)165(106(17)25-3)260-182(305)121(228-111(22)268)44-36-78-220-205(215)216)200(323)241-128(61-69-150(212)274)178(301)232-123(43-32-35-77-209)176(299)251-144(95-265)195(318)247-140(89-159(288)289)190(313)234-125(62-70-154(278)279)172(295)222-91-152(276)229-141(87-116-90-219-98-224-116)204(327)262-80-38-46-147(262)196(319)248-137(83-112-39-28-27-29-40-112)185(308)233-124(45-37-79-221-206(217)218)173(296)225-108(19)168(291)242-135(84-113-47-53-117(269)54-48-113)187(310)244-133(81-99(5)6)184(307)236-131(65-73-157(284)285)181(304)252-143(94-264)192(315)238-132(66-74-158(286)287)183(306)256-161(102(11)12)197(320)227-110(21)170(293)259-164(105(16)24-2)203(326)254-146(97-267)193(316)237-129(63-71-155(280)281)179(302)235-130(64-72-156(282)283)180(303)243-134(82-100(7)8)191(314)257-162(103(13)14)198(321)239-127(60-68-149(211)273)177(300)231-122(42-31-34-76-208)175(298)245-136(85-114-49-55-118(270)56-50-114)188(311)253-145(96-266)194(317)246-139(88-151(213)275)189(312)250-142(93-263)167(214)290;3-2(4,5)1(6)7/h27-29,39-40,47-58,90,98-110,120-147,160-166,263-267,269-271H,23-26,30-38,41-46,59-89,91-97,207-209H2,1-22H3,(H2,210,272)(H2,211,273)(H2,212,274)(H2,213,275)(H2,214,290)(H,219,224)(H,222,295)(H,223,294)(H,225,296)(H,226,297)(H,227,320)(H,228,268)(H,229,276)(H,230,309)(H,231,300)(H,232,301)(H,233,308)(H,234,313)(H,235,302)(H,236,307)(H,237,316)(H,238,315)(H,239,321)(H,240,324)(H,241,323)(H,242,291)(H,243,303)(H,244,310)(H,245,298)(H,246,317)(H,247,318)(H,248,319)(H,249,325)(H,250,312)(H,251,299)(H,252,304)(H,253,311)(H,254,326)(H,255,277)(H,256,306)(H,257,314)(H,258,292)(H,259,293)(H,260,305)(H,261,322)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H4,215,216,220)(H4,217,218,221);(H,6,7)/t104-,105-,10
InChi Key
KZHMYCJISUXHLJ-GMMCLIGKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Nogo-66 (1-40) is a peptide fragment of Nogo-A that corresponds to the extracellular domain, Nogo-66, which can induce neurite growth cone collapse in oligodendrocytes.1,2 It is also an antagonist of the Nogo-66 receptor (NgR).2 It inhibits binding of the NgR agonist AP-Nogo-66 to, and inhibits growth cone collapse induced by the NgR agonist GST-Nogo-66 in, embryonic day 12 (E12) chick dorsal root ganglia (DRG) explants.2 Nogo-66 (1-40) partially reverses axonal outgrowth inhibition induced by purified CNS myelin in E12 chick DRG explants (EC50 = 50 nM). It also induces regeneration of corticospinal tract fibers and improves locomotor function in a rat model of midthoracic spinal cord hemisection injury when administered intrathecally at a dose of 75 µg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lim, M., Shi, J., Wei, Z., et al. Structural characterization of the human Nogo-A functional domains. Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regeneration. Eur. J. Biochem. 271(17), 3512-3522 (2004).

    2. GrandPré, T., Li, S., and Strittmatter, S.M. Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature 417(6888), 547-551 (2002).