An active metabolite of nabumetone
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Parent Compound(s)
20251Nabumetone
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6-methoxy-2-Naphthoic Acid

Item No. 35374

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-methoxy-2-naphthalenecarboxylic acid
CAS Number
2471-70-7
Synonyms
  • 6-methoxy Naphthalene Acetic Acid
  • 6-methoxy-2-Naphthylacetic Acid
  • 6-MNA
  • NSC 408786
Molecular Formula
C12H10O3
Formula Weight
202.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 3 mg/mlEthanol: 3 mg/ml
λmax
237, 243 nm
SMILES
COC1=CC2=C(C=C1)C=C(C(O)=O)C=C2
InChi Code
InChI=1S/C12H10O3/c1-15-11-5-4-8-6-10(12(13)14)3-2-9(8)7-11/h2-7H,1H3,(H,13,14)
InChi Key
YZBILXXOZFORFE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 g

    $35

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    5 g

    $109

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    10 g

    $201

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    25 g

    $377

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    Product Description

    6-methoxy-2-Naphthoic acid (6-MNA) is an active metabolite of the non-steroidal anti-inflammatory drug (NSAID) nabumetone (Item No. 20251).1,2 It inhibits COX-1 and LPS-induced COX-2 activities in isolated human whole blood (IC50s = 31.01 and 19.84 µM, respectively).2 6-MNA is also a potential impurity in commercial preparations of naproxen.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ray, J.E., and Day, R.O. High-performance liquid chromatographic determination of a new anti-inflammatory agent, nabumetone, and its major metabolite in plasma using fluorimetric detection. J. Chromatogr. 336(1), 234-238 (1984).

    2. Cryer, B., and Feldman, M. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs. Am. J. Med. 104(5), 413-421 (1998).

    3. Hrk, M., Babu, K.S., Lanka, A.R.P., et al. Simultaneous estimation of related compounds in esomeprazole and naproxen tablets by using ion pair reverse phase HPLC. Int. J. Pharm. Pharm. Sci. 7(2), 460-464 (2015).