A potential impurity found in bulk preparations of rosuvastatin
Related Products
Isomer(s)
44550Rosuvastatin (sodium salt)
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(3R,5R)-Rosuvastatin (calcium salt)

Item No. 35381

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,5R,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid, hemicalcium salt
CAS Number
1422515-55-6
Molecular Formula
C22H28FN3O6S • 1/2Ca
Formula Weight
500.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble
λmax
242, 310 nm
SMILES
CS(N(C)C1=NC(C(C)C)=C(C(C2=CC=C(C=C2)F)=N1)/C=C/[C@H](O)C[C@@H](O)CC([O-])=O)(=O)=O.CS(N(C)C3=NC(C(C)C)=C(C(C4=CC=C(C=C4)F)=N3)/C=C/[C@H](O)C[C@@H](O)CC([O-])=O)(=O)=O.[Ca+2]
InChi Code
InChI=1S/2C22H28FN3O6S.Ca/c2*1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32;/h2*5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30);/q;;+2/p-2/b2*10-9+;/t2*16-,17+;/m00./s1
InChi Key
LALFOYNTGMUKGG-UJPABJLRSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $124

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    (3R,5R)-Rosuvastatin is a potential impurity found in bulk preparations of the HMG-CoA reductase inhibitor rosuvastatin.1 It is a degradation product formed by acid or base hydrolysis, thermal, photolytic, hydrolytic, or oxidative stress, or during storage.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Koppala, S., Rayam, P., Reddy, V.R., et al. Identification, isolation, characterization and quantification of a new impurity in rosuvastatin calcium tablet dosage form. Anal. Chem. Ind. J. 16(10), 417-432 (2016).