An HMG-CoA reductase inhibitor
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Rosuvastatin (sodium salt)

Item No. 44550

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid, monosodium salt
CAS Number
147098-18-8
Synonyms
  • ZD 4522
Molecular Formula
C22H27FN3O6S • Na
Formula Weight
503.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Soluble: ≥ 10 mg/ml
SMILES
O[C@@H](C[C@@H](O)CC([O-])=O)/C=C/C(C(C1=CC=C(F)C=C1)=NC(N(C)[S](C)(=O)=O)=N2)=C2C(C)C.[Na+]
InChi Code
InChI=1S/C22H28FN3O6S.Na/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32;/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30);/q;+1/p-1/b10-9+;/t16-,17-;/m1./s1
InChi Key
RGEBGDYYHAFODH-DHMAKVBVSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 mg

    $54

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    50 mg

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    100 mg

    $140

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    Product Description

    Rosuvastatin is an inhibitor of HMG-CoA reductase (IC50 = 5 nM).1 It inhibits cholesterol synthesis in isolated rat hepatocytes with an IC50 value of 0.16 nM.2 Rosuvastatin (10 mg/kg) reduces plasma total cholesterol, triglyceride, LDL-C, and oxidized LDL-C levels in Ldlr-/- mice fed a high-fat diet.3 It decreases the area of aortic atherosclerotic lesions in the same model. Formulations containing rosuvastatin have been used in the treatment of dyslipidemias.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Istvan, E.S., and Deisenhofer, J. Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292(5519), 1160-1164 (2001).

    2. McTaggart, F., Buckett, L., Davidson, R., et al. Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Am. J. Cardiol. 87(5A), 28B-32B (2001).

    3. Guo, H., Shi, Y., Liu, L., et al. Rosuvastatin inhibits MMP-2 expression and limits the progression of atherosclerosis in LDLR-deficient mice. Arch. Med. Res. 40(5), 345-351 (2009).