An inhibitor of Wee1
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Wee1 Inhibitor

Item No. 35391

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-chlorophenyl)-9-hydroxy-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
CAS Number
622855-37-2
Molecular Formula
C20H11ClN2O3
Formula Weight
362.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/mlEthanol: 10 mg/ml
SMILES
OC1=CC=C(N([H])C2=C3C4=C(C(N([H])C4=O)=O)C(C5=C(Cl)C=CC=C5)=C2)C3=C1
InChi Code
InChI=1S/C20H11ClN2O3/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(25)23-20(18)26)12-7-9(24)5-6-14(12)22-15/h1-8,22,24H,(H,23,25,26)
InChi Key
DPEXRCOBPACFOO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $288

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    Product Description

    Wee1 inhibitor is an inhibitor of the checkpoint kinase Wee1 (IC50 = 11 nM).1 It is selective for Wee1 over checkpoint kinase 1 (Chk1; IC50 = 440 nM). Wee1 inhibitor also inhibits the ATPase activity of LptB, an enzyme involved in the transport and assembly of LPS (IC50 = 25 µM for the E. coli enzyme).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Palmer, B.D., Thompson, A.M., Booth, R.J., et al. 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. J. Med. Chem. 49(16), 4896-4911 (2006).

    2. Gronenberg, L.S., and Kahne, D. Development of an activity assay for discovery of inhibitors of lipopolysaccharide transport. J. Am. Chem. Soc. 132(8), 2518-2519 (2010).