An alkaloid and GSK3β inhibitor
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Dihydronarwedine

Item No. 35409

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4aS,5,7,8aR,9,10,11,12-octahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one
CAS Number
21041-10-1
Synonyms
  • (–)-Dihydrogalanthaminone
  • (–)-Lycoraminone
Molecular Formula
C17H21NO3
Formula Weight
287.4
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: solubleDMSO: soluble
SMILES
COC1=C2C3=C(C=C1)CN(C)CC[C@@]34[C@@](CC(CC4)=O)([H])O2
InChi Code
InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-4,14H,5-10H2,1-2H3/t14-,17-/m0/s1
InChi Key
UFQNQEIAGBZCBL-YOEHRIQHSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $74

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    5 mg

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    10 mg

    $403

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    Product Description

    Dihydroarwedine is an alkaloid that has been found in N. pseudonarcissus and an inhibitor of glycogen synthase kinase 3β (GSK3β).1 It inhibits recombinant human GSK3β by 39% when used at a concentration of 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hulcová, D., Maříková, J., Korábečný, J., et al. Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer’s disease. Phytochemistry 165, 112055 (2019).