A leukotriene receptor antagonist
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FPL 55712 (sodium salt)

Item No. 35433

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid, monosodium salt
CAS Number
40786-08-1
Molecular Formula
C27H29O9 • Na
Formula Weight
520.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
214, 286 nm
SMILES
O=C(C(OC1=C(CCC)C(OCC(COC2=C(CCC)C(O)=C(C(C)=O)C=C2)O)=CC=C13)=CC3=O)[O-].[Na+]
InChi Code
InChI=1S/C27H30O9.Na/c1-4-6-19-22(10-8-17(15(3)28)25(19)31)34-13-16(29)14-35-23-11-9-18-21(30)12-24(27(32)33)36-26(18)20(23)7-5-2;/h8-12,16,29,31H,4-7,13-14H2,1-3H3,(H,32,33);/q;+1/p-1
InChi Key
ZDEVPOBNLIVGFA-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    FPL 55712 (sodium salt) is a leukotriene (LT) receptor antagonist.1 It inhibits the binding of LTD4 (Item No. 20310) to guinea pig lung homogenates (IC50 = 4 µM) and reduces LTD4-induced contraction of isolated guinea pig tracheal smooth muscle (pA2 = 1 µM). FPL 55712 (sodium salt) inhibits bronchoconstriction induced by LTD4, LTC4 (Item No. 20210), or LTE4 (Item No. 20410) in guinea pigs (ID50s = 2, 6, and 1 mg/kg, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cohen, N., Weber, G., Banner, B.L., et al. 3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonists. J. Med. Chem. 32(8), 1842-1860 (1989).