Cu-GTSM

Cu-GTSM is a copper-containing compound and an analog of Cu-ATSM (Item No. 17122) that has diverse biological activities.^1,2,3,4 It is active against methicillin-sensitive and -resistant S. aureus clinical isolates (IC₅₀s = 0.3-0.6 µM for all).¹ Cu-GTSM inhibits the growth of SK-N-MC neuroepithelioma cells and MRC-5 fibroblasts (IC₅₀s = 0.009 and 0.27 µM, respectively).² It induces the production of reactive oxygen species (ROS) in SK-N-MC cells when used at a concentration of 5 µM. Cu-GTSM (2.5 mg/kg) reduces tumor burden in the transgenic adenocarcinoma of mouse prostate (TRAMP) model but induces weight loss and renal toxicity in the same model.³ Cu-GTSM-containing positron-emitting copper isotopes have been used in PET imaging applications for copper trafficking in the TASTPM transgenic mouse model of Alzheimer's disease.⁴

WARNING This product is not for human or veterinary use.

1. Haeili, M., Moore, C., Davis, C.J.C., et al. Copper complexation screen reveals compounds with potent antibiotic properties against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 58(7), 3727-3736 (2014).

2. Stefani, C., Al-Eisawi, Z., Jansson, P.J., et al. Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization. J. Inorg. Biochem. 152, 20-37 (2015).

3. Cater, M.A., Pearson, H.B., Wolyniec, K., et al. Increasing intracellular bioavailable copper selectively targets prostate cancer cells. ACS Chem. Biol. 8(7), 1621-1631 (2013).

4. Torres, J.B., Andreozzi, E.M., Dunn, J.T., et al. PET imaging of copper trafficking in a mouse model of alzheimer disease. J. Nucl. Med. 57(1), 109-114 (2016).