A dopamine D4 receptor antagonist
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PD 168568 (hydrochloride)

Item No. 35483

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-one, dihydrochloride
CAS Number
1782532-06-2
Molecular Formula
C22H27N3O • 2HCl
Formula Weight
422.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMWater: 50 mM
SMILES
O=C1NC(CCN2CCN(CC2)C3=CC(C)=C(C)C=C3)C4=CC=CC=C14.Cl.Cl
InChi Code
InChI=1S/C22H27N3O.2ClH/c1-16-7-8-18(15-17(16)2)25-13-11-24(12-14-25)10-9-21-19-5-3-4-6-20(19)22(26)23-21;;/h3-8,15,21H,9-14H2,1-2H3,(H,23,26);2*1H
InChi Key
RMNWLEGGYCVHFD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

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    10 mg

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    25 mg

    $404

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    Cayman Chemical
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    Product Description

    PD 168568 is a dopamine D4 receptor antagonist (Ki = 8.8 nM).1 It is selective for dopamine D4 over D2 receptors (Ki = 1,842 nM). PD 168568 (3 mg/kg) reverses amphetamine-induced hyperlocomotion in rats. It also inhibits the growth of glioblastoma neural stem cells when used at concentrations of 25 and 50 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Belliotti, T.R., Brink, W.A., Kesten, S.R., et al. Isoindolinone enantiomers having affinity for the dopamine D4 receptor. Bioorg. Med. Chem. Lett. 8(12), 1499-1502 (1998).

    2. Dolma, S., Selvadurai, H.J., Lan, X., et al. Inhibition of dopamine receptor D4 impedes autophagic flux, proliferation, and survival of glioblastoma stem cells. Cancer Cell 29(6), 859-873 (2016).